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Essential Biochemistry - Nucleic Acid Metabolism (Section 4)

1
What is the end product of purine catabolism?
Answer
(A)
Uric acid
2
What is the primary product of purine catabolism?
Answer
(B)
Uric acid
3
Which of the following is a common treatment for gout?
Answer
(D)
Avoidance of purine rich foods
4
Which enzyme is responsible for the formation of adenylate (AMP) from IMP?
Answer
(A)
Adenylosuccinate synthetase
5
Which enzyme is inhibited by allopurinol?
Answer
(B)
Xanthine oxidase
6
Which of the following is a source of nitrogen in pyrimidine ring?
Answer
(C)
Glutamine
7
In the biosynthesis of pyrimidines, which of the following serve as the nitrogen donors?
Answer
(B)
Glutamine
8
What are the building blocks for pyrimidine synthesis?
Answer
(A)
CO2, Aspartate, Glutamine
9
What is the primary role of adenosine deaminase (ADA)?
Answer
(A)
Convert adenosine to inosine
10
What is the role of dihydrofolate reductase in nucleotide metabolism?
Answer
(B)
It reduces dihydrofolate to tetrahydrofolate