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Essential Biochemistry - Detoxification (metabolism Of Xenobiotics) (Section 3)

1
Which phase usually follows after Phase I?
Answer
(C)
Phase II
2
What is the role of glutathione in detoxification?
Answer
(B)
Conjugates with xenobiotics
3
Which of the following are xenobiotics?
Answer
A
B
C
4
Biotransformation by oxidation is catalyzed by:
Answer
(D)
Cytochrome P450
5
What is the main goal of detoxification?
Answer
(B)
To convert lipophilic compounds to more water-soluble forms
6
The primary purpose of biotransformation is to:
Answer
(A)
Convert lipophilic compounds to more polar compounds
7
Which of the following is used for acetylation?
Answer
(A)
Acetyl-CoA
8
What is the end product of the conjugation reaction between benzoic acid and glycine?
Answer
(A)
Hippuric acid
9
What is the role of phase I reactions in xenobiotic metabolism?
Answer
(D)
All of the above
10
What does phase II reactions convert the products of phase I reactions into?
Answer
(A)
Polar metabolites
11
What is the name of the enzyme used in conjugation with Glucuronic acid?
Answer
(A)
Glucuronyl transferase
12
What is the result of oxidative deamination of amines?
Answer
(A)
Corresponding acids and nitrogen