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Essential Biochemistry - Chemistry Of Hemoglobin (Section 2)

1
What type of bond is formed between iron atom and porphyrin ring?
Answer
(D)
Coordinate bond
2
Which condition is associated with an increased HbA2 level?
Answer
(B)
Beta-thalassemia
3
What is carboxyhemoglobin?
Answer
(C)
Hemoglobin bound to carbon monoxide
4
What is the function of 2,3-BPG?
Answer
B
C
D
5
What is the role of histidine in the globin chain?
Answer
(B)
To bind the iron atom in heme
6
Which of the following is a derivative of abnormal hemoglobin?
Answer
(B)
Carboxyhemoglobin
7
What is the composition of HbA2?
Answer
(B)
α2δ2
8
Give reasons for the sickling of RBC.
Answer
A
B
9
What is the role of the iron atom within the heme group?
Answer
(B)
To bind and carry oxygen
10
What is the name for hemoglobin with oxygen bound to it?
Answer
(B)
Oxyhemoglobin
11
What is the role of 2,3-Bisphosphoglycerate (2,3-BPG) in hemoglobin?
Answer
(B)
Decreases the affinity of hemoglobin for oxygen.
12
What is the cause of sickle cell anemia?
Answer
(B)
Mutation in the beta-globin gene.
13
Which of the following describes the effect of CO2 on oxygen binding to hemoglobin?
Answer
(B)
Decreases oxygen binding affinity
14
Which of the following is primarily responsible for the characteristic red color of blood?
Answer
(B)
The iron atom in heme
15
Which of the following describes the 'Tense (T) form' of hemoglobin?
Answer
(C)
It has a low affinity for oxygen.
16
What is the Bohr effect?
Answer
(C)
The effect of pH and CO2 on oxygen binding to hemoglobin.
17
Which of the following are the types of hemoglobin?
Answer
A
B
D
18
What are the consequences in sick cell anemia?
Answer
A
B
C
D
19
Which of the following best describes the role of the porphyrin ring in hemoglobin?
Answer
(B)
Forms a complex with iron
20
Which of the following is a characteristic of thalassemia?
Answer
(B)
Defective globin chain synthesis
21
What is the primary function of hemoglobin?
Answer
(A)
Transport of oxygen and carbon dioxide.
22
Which of the following enhances the binding of oxygen to hemoglobin?
Answer
(C)
Decreased temperature
23
In the lungs, oxygen is high, and CO2 is low, thus the affinity of oxygen is:
Answer
(A)
High
24
Which of the following is a major form of adult hemoglobin?
Answer
(A)
HbA
25
Which of the following conditions is associated with a rightward shift in the oxygen-hemoglobin dissociation curve?
Answer
(C)
Increased CO2 levels
26
What would have a protective effect against malaria?
Answer
(C)
HbS
27
What is the function of the heme group in hemoglobin?
Answer
(B)
To bind oxygen
28
What is the effect of decreased pH on the oxygen-hemoglobin binding?
Answer
(B)
Decreases the affinity
29
What is the effect of increased carbon dioxide on the oxygen affinity of hemoglobin?
Answer
(B)
Decreases affinity
30
Which type of hemoglobin is predominantly found in a normal adult?
Answer
(B)
HbA
31
Which of the following is the correct binding site for the bicarbonate ion in hemoglobin?
Answer
(D)
The globin chains.
32
Which of the following is/are directly involved in stabilizing the T form of hemoglobin?
Answer
A
B
C
33
Which of the following is/are involved in the stabilization of the deoxy (T) form of hemoglobin?
Answer
A
B
C
34
Which of the following conditions can lead to the formation of carboxyhemoglobin?
Answer
(B)
Exposure to carbon monoxide
35
Which of the following is an example of a cooperative protein?
Answer
(B)
Hemoglobin
36
What is the primary function of the heme group within the hemoglobin molecule?
Answer
(B)
To bind oxygen and transport it to the tissues.
37
What are the main functions of Hemoglobin?
Answer
A
B
C
38
Which of the following is an example of an abnormal hemoglobin derivative?
Answer
(C)
Carboxyhemoglobin
39
Normal adult hemoglobin (HbA) has the following chains:
Answer
(A)
α₂β₂
40
Which of the following are abnormal hemoglobin derivatives?
Answer
A
B
41
What does the term 'thalassemia' refer to?
Answer
(B)
A group of genetic blood disorders affecting hemoglobin production
42
Which of the following is a normal derivative of hemoglobin?
Answer
(C)
Oxyhemoglobin
43
What is the name of the bond formed between iron and the porphyrin ring in heme?
Answer
(B)
Coordinate covalent bond
44
What is the effect of increased CO₂ concentration on the binding of oxygen to hemoglobin?
Answer
(B)
Decreases the binding affinity
45
Which of the following is NOT a characteristic of sickle cell anemia?
Answer
(D)
It is caused by a deficiency in iron.
46
What is the significance of the sigmoidal shape of the oxygen-hemoglobin dissociation curve?
Answer
(B)
It reflects the cooperative binding of oxygen to hemoglobin.
47
What is methemoglobin?
Answer
(B)
Hemoglobin in which the iron is in the ferric (Fe³⁺) state
48
Which type of anemia is caused by defective synthesis of globin chains?
Answer
(C)
Thalassemia
49
Which of the following statements is true about HbF?
Answer
(C)
It has a higher affinity for oxygen than HbA
50
What does the shift to the right of the oxygen-hemoglobin dissociation curve indicate?
Answer
(B)
Decreased oxygen affinity