Quick Biochemistry - Proteins And Protein Metabolism (Section 2 - No. 28)
What is the main biochemical issue in those with familial hypercholesterolemia (type IIa)?
Loss of feed back inhibition of HMG reductase
Loss of apolipoprotein B
Increased production of LDL from VLDL
Functional deficiency of plasma membrane receptors for LDL
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