This problem is solved using gap method. As here no 'S' is adjacent to each other so we have to put them in the gap. So first write all the letters other than 'S' such a way that there is a gap between two letters.

Given word is MISSISSIPPI.

Here, I = 4 times, S = 4 times, P = 2 times, M = 1 time

_M_I_I_I_I_P_P_

Those seven letters M, I, I, I, I, P, P can be arranged in $${{7!} \over {4!2!}}$$ ways

Those seven letters creates 8 gaps and we have to choose 4 gaps from those 8 gaps to put those four 'S' letters.

This can be done $${}^8{C_4}$$ ways.

After placing those four 'S' letters we can arrange them in $${{4!} \over {4!}}$$ ways.

Therefore, required number of words

$$ = {{7!} \over {4!2!}} \times {}^8{C_4} \times {{4!} \over {4!}}$$

$$ = {{7\,.\,6!} \over {4!4!}} \times {}^8{C_4}$$

$$ = 7\,.\,{}^6{C_4}\,.\,{}^8{C_4}$$