During the Last Supper, Jesus used bread and wine as symbols of His body and blood, instituting what is now known as the Holy Communion (Eucharist).

Biblical Reference (Luke 22:19-20, RSV):

"And he took bread, and when he had given thanks he broke it and gave it to them, saying, ‘This is my body which is given for you. Do this in remembrance of me.’ And likewise the cup after supper, saying, ‘This cup which is poured out for you is the new covenant in my blood.’”