A macromolecule is a very large molecule, usually with a diameter of 100 to 10,000 angstroms (10−5 to 10−3 mm). 

Nylon is a synthetic macromolecule that's made up of repeating subunits called monomers. It's created through a condensation polymerization reaction between adipic acid and hexamethylene diamine.

Polyethylene is a synthetic polymer, which means it's made by scientists and engineers from petroleum oil.

Creatine is a non-protein compound that is derived from amino acids, and is produced in the body by the liver, kidneys, and pancreas. It is also found in protein-rich foods like meat, fish, and milk.

 Hemoglobin is a natural organic(natural) macromolecule.