Essential Biochemistry - Nucleic Acid Metabolism (Section 3 - No. 39)
Which of the following is the committed step for pyrimidine synthesis?
Synthesis of carbamoyl phosphate by CPSII
Formation of orotic acid
Conversion of UMP to CTP
Conversion of orotic acid to UMP
Explanation
The synthesis of carbamoyl phosphate by CPSII is the first committed step in pyrimidine synthesis.
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