Essential Biochemistry - Nucleic Acid Metabolism (Section 3 - No. 33)

Which enzyme is primarily responsible for the synthesis of pyrimidine nucleotides?

Aspartate transcarbamoylase

Dihydroorotase

Uracil phosphoribosyltransferase

Orotate phosphoribosyltransferase

Aspartate transcarbamoylase catalyzes the first committed step of pyrimidine synthesis.