Essential Biochemistry - Nucleic Acid Metabolism (Section 3 - No. 30)
Which of the following enzymes is deficient in Lesch-Nyhan syndrome?
PRPP synthetase
Glutamine-PRPP amidotransferase
HGPRT
Adenylosuccinate synthetase
Explanation
Lesch-Nyhan syndrome is caused by a deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT).
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