Essential Biochemistry - Nucleic Acid Metabolism (Section 1 - No. 26)
Which of the following is a characteristic of type I orotic aciduria?
Deficiency in both orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase.
Excessive levels of pyrimidine nucleotides.
Inability to synthesize UMP from orotate.
All of the above.
Explanation
Type I orotic aciduria is the deficiency of both enzymes.
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