Essential Biochemistry - Lipid Metabolism (Section 8 - No. 12)
What is the committed step in fatty acid synthesis?
The carboxylation of acetyl-CoA to malonyl-CoA
The condensation of acetyl-CoA and malonyl-CoA
The reduction of the carbonyl group to a hydroxyl group
The dehydration of a β-hydroxyacyl-ACP
Explanation
The carboxylation of acetyl-CoA to malonyl-CoA, catalyzed by acetyl-CoA carboxylase, is the committed step.
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