Essential Biochemistry - Lipid Metabolism (Section 5 - No. 16)
A 55-year-old man had elevated serum cholesterol level. He started to take simvastatin and 3 months later his cholesterol was normal. Which enzyme of cholesterol biosynthesis is inhibited by simvastatin?
HMG-CoA reductase
Acetyl CoA carboxylase
Lipoprotein lipase
Lecithin-cholesterol acyltransferase (LCAT)
Explanation
Simvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis.
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