Essential Biochemistry - Lipid Metabolism (Section 3 - No. 10)
Which of the following is the committed step of fatty acid synthesis?
Formation of malonyl-CoA
Formation of acetyl-CoA
Condensation of Acetyl-CoA and Malonyl-CoA
Reduction of a ketoacyl group
Explanation
The formation of malonyl-CoA from acetyl-CoA, catalyzed by acetyl-CoA carboxylase, is the committed step.
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