Essential Biochemistry - Lipid Metabolism (Section 2 - No. 10)
Which of the following intermediates in the oxidation of odd-chain fatty acids is likely to appear in the urine in vitamin B12 deficiency?
Succinic acid
Methylmalonic acid
Propionic acid
Butyric acid
Explanation
Methylmalonic acid accumulates due to the impaired activity of methylmalonyl-CoA mutase, which requires vitamin B12
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