Essential Biochemistry - Lipid Metabolism (Section 11 - No. 43)

Which enzyme catalyzes the committed step of fatty acid synthesis?
Fatty acid synthase
Acetyl-CoA carboxylase
Citrate synthase
Malate dehydrogenase

Explanation

Acetyl-CoA carboxylase catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA, the rate-limiting step.

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