Essential Biochemistry - Lipid Metabolism (Section 11 - No. 19)
Which of the following is a key regulatory step in fatty acid synthesis?
The conversion of acetyl-CoA to malonyl-CoA by acetyl-CoA carboxylase.
The oxidation of fatty acyl-CoA by acyl-CoA dehydrogenase.
The entry of fatty acids into the mitochondria via the carnitine shuttle.
The hydrolysis of triglycerides by lipoprotein lipase.
Explanation
The conversion of acetyl-CoA to malonyl-CoA by acetyl-CoA carboxylase is the committed and rate-limiting step in fatty acid synthesis.
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