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Essential Biochemistry - Enzymes (Section 4)

1
Asparaginase is primarily used to treat which disease?
Answer
(B)
Leukemia
2
Enzyme activity in biological systems may be affected by the following:
Answer
A
B
C
D
3
Penicillin belongs to which type of inhibitors?
Answer
(C)
Suicide
4
The enzyme that is useful in the treatment of leukemia is:
Answer
(A)
Asparaginase
5
Which is a key difference between isozymes?
Answer
(B)
Their amino acid sequence.
6
Which of the following is an example of a coenzyme?
Answer
(C)
Vitamin B12
7
An irreversible inhibitor bonds with an enzyme:
Answer
(D)
Irreversibly and forms a stable complex.
8
In feedback allosteric inhibition, the enzyme that is inhibited is:
Answer
(B)
The first enzyme in the pathway
9
Isozymes are classified according to:
Answer
(B)
The type of catalyst
10
LDH1 is a tetramer, and its subunits consist of:
Answer
(B)
M and H
11
The functional difference between isozymes lies in:
Answer
(D)
Their amino acid sequence.
12
CK-MB is found in:
Answer
(A)
Heart muscle
13
In patients with obstructive jaundice, which enzyme levels are usually elevated?
Answer
B
C
14
What enzymes will likely be elevated in obstructive jaundice?
Answer
B
C
15
CK-MB is predominantly found in:
Answer
(A)
Cardiac muscle
16
Which of the following is not a type of enzyme specificity?
Answer
(D)
Broad Specificity
17
All of the following serum enzymes are elevated in myocardial infarction, except:
Answer
(A)
Alkaline phosphatase
18
Allosteric enzymes are regulated by a substance binding to:
Answer
(B)
Allosteric site
19
Which enzymes are commonly elevated in the context of obstructive jaundice?
Answer
B
C
20
The isozymes are classified less into main classes according to the type of:
Answer
(A)
Catalyst
21
Which of the following is a group-specific irreversible inhibitor?
Answer
(A)
DDT (DFP)
22
Isozymes catalyze ________ reactions.
Answer
(B)
The same
23
Allosteric regulation involves binding at the:
Answer
(B)
Allosteric site
24
How does an irreversible inhibitor typically bind to an enzyme?
Answer
(B)
Irreversibly
25
Penicillin's inhibition mechanism can be described as:
Answer
(B)
Suicide inhibition.
26
LDH1 is composed of what combination of subunits?
Answer
(A)
M and H
27
A characteristic of irreversible inhibitors is that they:
Answer
(B)
Often form covalent bonds with the enzyme.
28
What is the general function of oxidoreductase enzymes?
Answer
(B)
Catalyzing oxidation-reduction reactions.
29
The Michaelis constant (Km) is:
Answer
(C)
The substrate concentration at 1/2 Vmax
30
Which of the following is NOT a characteristic of noncompetitive inhibitors?
Answer
(C)
They affect the Km.
31
Which enzyme is used to treat leukemia?
Answer
(A)
Asparaginase
32
Irreversible inhibitors bind to the enzyme with:
Answer
(B)
Strong affinity
33
Enzymes increase reaction rate by:
Answer
(D)
Decreasing the rate of activation
34
Penicillin is best described as which type of inhibitor?
Answer
(B)
Suicide
35
Which of the following is a key factor influencing enzyme activity?
Answer
(D)
All of the above
36
LDH1 is primarily found in:
Answer
(A)
Heart
37
Which of the following enzyme levels increases in obstructive jaundice?
Answer
B
C
38
The alkaline phosphatases belong to:
Answer
A
C
39
The optimum temperature for most enzymes is:
Answer
(B)
37°C
40
Which model is more accurate to describe the specific interactions between the enzyme and the substrate?
Answer
(B)
Induced Fit Model
41
Allosteric enzymes are regulated by binding at the:
Answer
(B)
Regulatory site
42
Aspirin inhibits the enzyme:
Answer
(B)
Cyclooxygenase
43
Isozymes are different forms of an enzyme that:
Answer
(B)
Catalyze the same reaction
44
DDT can inhibit which enzyme?
Answer
(A)
Acetylcholine esterase
45
Which of the following is the function of an inhibitor?
Answer
(B)
Decreases enzyme activity
46
Irreversible inhibitors generally interact with enzymes through what type of bonds?
Answer
(B)
Covalent bonds
47
The enzyme acetylcholine esterase is inhibited by:
Answer
(A)
DDT (DFP)
48
Isozymes can be characterized as:
Answer
(D)
Multiple forms of given enzyme that catalyze same type of reactions
49
The mechanism of action for Penicillin involves:
Answer
(B)
Suicide Inhibition
50
Which factors are involved in the activation of the enzyme's activity?
Answer
A
B