Essential Biochemistry - Enzymes (Section 1 - No. 33)
What would be the effect of a non-competitive inhibitor on a Lineweaver-Burk plot?
The y-intercept changes and the x-intercept remains the same.
The x-intercept changes and the y-intercept remains the same.
Both the x and y intercepts change.
Neither intercept changes.
Explanation
Noncompetitive inhibitors alter the Vmax, hence the y-intercept will change, while the Km, and therefore the x-intercept, will remain the same.
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