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Essential Biochemistry - Connective Tissue (Section 2)

1
Which of the following amino acids is NOT typically found in collagen?
Answer
(D)
Cysteine
2
What type of bond stabilizes the triple helix structure of collagen?
Answer
(B)
Hydrogen bonds
3
Which of the following best describes the structure of elastin?
Answer
(C)
Rubber-like protein
4
Collagen contents of helix destabilizing amino acid is:
Answer
(A)
Glycine
5
What is the role of hyaluronic acid, chondroitin sulfate, and heparin in connective tissue?
Answer
(B)
They are the major glycosaminoglycans
6
Where are the majority of elastin fibers found?
Answer
(D)
Blood vessels
7
Hydroxylation of proline requires which of the following?
Answer
(D)
All of the above
8
The basic subunit of elastic fibrils is:
Answer
(B)
Tropoelastin
9
Which of the following are disorders of connective tissue?
Answer
A
B
D
10
Which enzyme is required for the cross-linking of collagen chains?
Answer
(B)
Lysyl oxidase
11
What condition results from a deficiency in ascorbic acid (vitamin C)?
Answer
(B)
Scurvy
12
Which type of cross-links stabilize the collagen fibril?
Answer
A
C
D
13
What is the primary genetic defect in osteogenesis imperfecta?
Answer
(C)
Multiple genetic defects in type-I collagen synthesis
14
Which of the following is not a genetic disorder of collagen?
Answer
(C)
Scurvy
15
A deficiency of copper affects the formation of normal collagen by reducing the activity of:
Answer
(B)
Lysyl oxidase