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Essential Biochemistry - Connective Tissue (Section 1)

1
Which of the following is directly involved in the formation of a collagen fibril?
Answer
(A)
Tropocollagen molecules
2
What is the main function of ground substance in connective tissue?
Answer
(C)
Bind and support cells
3
What disease is caused by a deficiency in ascorbic acid (vitamin C)?
Answer
(B)
Scurvy
4
What type of cross-links are present in elastin?
Answer
(B)
Desmosine
5
Which amino acids are frequently found in elastin?
Answer
A
B
C
6
Which of the following is a basic component of connective tissue?
Answer
(B)
Collagen
7
Which of the following is found in large amounts in connective tissues that require elasticity?
Answer
(B)
Elastin
8
Cross-links present in collagen are, except:
Answer
(D)
Desmosine
9
What is the role of Vitamin C in collagen synthesis?
Answer
(B)
A cofactor in hydroxylation reactions
10
Hydroxylation of proline requires which of the following?
Answer
(D)
All of the above
11
What is the main difference between collagen and elastin regarding their ability to stretch?
Answer
(B)
Elastin can stretch and recoil, collagen cannot.
12
Which amino acid is crucial for the triple helix structure of collagen?
Answer
(B)
Glycine
13
Which amino acid is crucial for the stabilization of the collagen helix?
Answer
(A)
Glycine
14
A deficiency of copper affects the formation of normal collagen by reducing the activity of:
Answer
(B)
Lysyl oxidase
15
What type of collagen is found in basement membranes?
Answer
(D)
Type IV
16
Which of the following is a characteristic of Ehlers-Danlos syndrome?
Answer
(A)
Skin hypermobility
17
The basic subunit of elastic fibrils is:
Answer
(B)
Tropoelastin
18
What type of connective tissue is mainly affected in Marfan's syndrome?
Answer
(B)
Elastic fibers
19
In which condition is the dermis characterized by skin breaks and blistering?
Answer
(D)
Epidermolysis bullosa
20
Collagen contents of helix destabilizing amino acid is:
Answer
(A)
Glycine
21
Which of the following components are found in the extracellular matrix of connective tissue?
Answer
A
B
C
22
Basic components of connective tissue are, except:
Answer
(D)
Cholesterol
23
Which of the following is a characteristic of Marfan's Syndrome?
Answer
(D)
Dislocation of the lens
24
What is the role of lysyl oxidase in collagen formation?
Answer
(B)
Forms cross-links
25
What type of bond stabilizes the triple helix of collagen?
Answer
(B)
Hydrogen bonds
26
What is the role of proteoglycans in connective tissue?
Answer
(B)
Bind and retain water
27
Which of the following is NOT a type of cross-link in collagen?
Answer
(D)
Desmosine
28
Which of these is a symptom of Scurvy?
Answer
(B)
Easy bruising and bleeding
29
What is the function of elastin in connective tissue?
Answer
(C)
Provide elasticity
30
Which type of collagen is most abundant in skin?
Answer
(A)
Type I
31
What is the primary function of connective tissue?
Answer
(C)
Support, strength, and shape
32
Which of the following is a characteristic of osteogenesis imperfecta?
Answer
(B)
Fragile bones
33
What is the primary function of glycoproteins in connective tissue?
Answer
(B)
Facilitate cell adhesion
34
What are the building blocks of tropocollagen?
Answer
(B)
Polypeptide chains
35
Which of the following is not a genetic disorder of collagen?
Answer
(C)
Scurvy
36
Which of the following is NOT a characteristic of collagen?
Answer
(D)
Ability to stretch and recoil
37
What is the role of hydrogen bonds in the collagen structure?
Answer
(B)
They stabilize the collagen chains.
38
Which of the following is NOT a glycosaminoglycan (GAG)?
Answer
(D)
Collagen
39
Which enzyme is inhibited in Lathyrism?
Answer
(A)
Lysyl oxidase
40
Which of the following is a dietary disorder related to connective tissue?
Answer
(B)
Lathyrism
41
What is the primary function of glycoproteins in connective tissue?
Answer
(B)
To facilitate adhesion
42
What is the main difference between collagen and elastin?
Answer
(B)
Elastin has no repeating sequences while collagen does.
43
Which amino acids are crucial for the unique structure of collagen?
Answer
A
B
D
44
Cross-links present in collagen are, except:
Answer
(D)
Desmosine
45
What is a characteristic feature of Marfan's syndrome?
Answer
B
D
46
What is the primary function of collagen in connective tissue?
Answer
(B)
To provide tensile strength and support
47
Which of the following is NOT a type of collagen?
Answer
(D)
Type X
48
Which of the following are NOT usually found in the extracellular matrix of connective tissue?
Answer
(D)
Myofibrils
49
Basic components of connective tissue are, except:
Answer
(D)
Cholesterol
50
What is the consequence of the destruction of elastin by elastase?
Answer
(A)
Emphysema