Essential Biochemistry - Chemistry Of Hemoglobin (Section 4 - No. 9)
In the context of sickle cell anemia, what does the 'sticky patch' on the HbS molecule cause?
Increased oxygen affinity
Decreased oxygen affinity
Polymerization of HbS molecules
Increased production of HbF
Explanation
The sticky patch on HbS molecules promotes polymerization, causing the red blood cells to sickle.
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