Essential Biochemistry - Chemistry Of Hemoglobin (Section 4 - No. 6)

The binding sites for oxygen, hydrogen, and carbon dioxide are
Fe²⁺ atoms of the heme
α chain
Histidine residues
C-terminal end of each of the polypeptide chains

Explanation

Oxygen binds to the iron atoms (Fe²⁺) of the heme, hydrogen binds to histidine residues, and carbon dioxide binds to the C-terminal end.

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