Essential Biochemistry - Chemistry Of Hemoglobin (Section 4 - No. 32)
What causes the 'sticky patch' in sickle cell hemoglobin (HbS) that leads to polymerization?
The presence of the alpha chains.
The substitution of valine for glutamic acid.
The addition of oxygen to the heme group.
The high concentration of carbon dioxide.
Explanation
The substitution of valine for glutamic acid in HbS causes a sticky patch.
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