Essential Biochemistry - Chemistry Of Hemoglobin (Section 4 - No. 11)
Give cause for the sickling of RBC:
Glutamic acid is present instead of valine in Hb
Valine is present instead of glutamic acid in Hb
Glycine is present instead of valine in Hb
No change in the Hb sequence
Explanation
In sickle cell anemia, valine replaces glutamic acid in the Hb molecule causing sickling of RBCs.
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