Essential Biochemistry - Chemistry Of Hemoglobin (Section 3 - No. 24)
What causes the sickling of red blood cells in sickle cell anemia?
A deficiency in iron.
Abnormal hemoglobin (HbS) polymerizing under low oxygen conditions.
Excessive production of HbA.
High levels of 2,3-BPG.
Explanation
HbS polymerizes under low oxygen conditions, leading to sickling.
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