Essential Biochemistry - Chemistry Of Hemoglobin (Section 1 - No. 17)
What causes methemoglobinemia?
Binding of carbon monoxide to hemoglobin
Oxidation of ferrous iron in hemoglobin
Deficiency of vitamin B12
Mutation in the beta-globin chain
Explanation
Methemoglobinemia is caused by the oxidation of iron in hemoglobin (Fe2+ to Fe3+).
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