Essential Biochemistry - Carbohydrate Metabolism (Section 6 - No. 17)

What is the first committed step in gluconeogenesis?

Conversion of pyruvate to oxaloacetate

Conversion of oxaloacetate to phosphoenolpyruvate

Conversion of glucose-6-phosphate to glucose

Conversion of fructose-1,6-bisphosphate to fructose-6-phosphate

The carboxylation of pyruvate to oxaloacetate is the first committed step, requiring pyruvate carboxylase.