Biology for IGCSE & O level - Enzymes (Section 3 - No. 29)
How does a change in pH affect the shape of an enzyme?
It has no effect on the shape.
It causes the enzyme to become more efficient.
It can alter the shape of the active site, potentially denaturing the enzyme.
It only affects the speed of the reaction.
Explanation
Changes in pH can affect the shape of the enzyme, and particularly the active site, because pH can disrupt the bonds (like hydrogen bonds) that maintain the enzyme's shape. If the shape is changed then the active site might no longer be able to bind to the substrate.
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