Essential Biochemistry - Enzymes (Section 4)

  • 1
    Asparaginase is primarily used to treat which disease?
    Antwoord
    (B)
    Leukemia
  • 2
    Enzyme activity in biological systems may be affected by the following:
    Antwoord
    A
    B
    C
    D
  • 3
    Penicillin belongs to which type of inhibitors?
    Antwoord
    (C)
    Suicide
  • 4
    The enzyme that is useful in the treatment of leukemia is:
    Antwoord
    (A)
    Asparaginase
  • 5
    Which is a key difference between isozymes?
    Antwoord
    (B)
    Their amino acid sequence.
  • 6
    Which of the following is an example of a coenzyme?
    Antwoord
    (C)
    Vitamin B12
  • 7
    An irreversible inhibitor bonds with an enzyme:
    Antwoord
    (D)
    Irreversibly and forms a stable complex.
  • 8
    In feedback allosteric inhibition, the enzyme that is inhibited is:
    Antwoord
    (B)
    The first enzyme in the pathway
  • 9
    Isozymes are classified according to:
    Antwoord
    (B)
    The type of catalyst
  • 10
    LDH1 is a tetramer, and its subunits consist of:
    Antwoord
    (B)
    M and H
  • 11
    The functional difference between isozymes lies in:
    Antwoord
    (D)
    Their amino acid sequence.
  • 12
    CK-MB is found in:
    Antwoord
    (A)
    Heart muscle
  • 13
    In patients with obstructive jaundice, which enzyme levels are usually elevated?
    Antwoord
    B
    C
  • 14
    What enzymes will likely be elevated in obstructive jaundice?
    Antwoord
    B
    C
  • 15
    CK-MB is predominantly found in:
    Antwoord
    (A)
    Cardiac muscle
  • 16
    Which of the following is not a type of enzyme specificity?
    Antwoord
    (D)
    Broad Specificity
  • 17
    All of the following serum enzymes are elevated in myocardial infarction, except:
    Antwoord
    (A)
    Alkaline phosphatase
  • 18
    Allosteric enzymes are regulated by a substance binding to:
    Antwoord
    (B)
    Allosteric site
  • 19
    Which enzymes are commonly elevated in the context of obstructive jaundice?
    Antwoord
    B
    C
  • 20
    The isozymes are classified less into main classes according to the type of:
    Antwoord
    (A)
    Catalyst
  • 21
    Which of the following is a group-specific irreversible inhibitor?
    Antwoord
    (A)
    DDT (DFP)
  • 22
    Isozymes catalyze ________ reactions.
    Antwoord
    (B)
    The same
  • 23
    Allosteric regulation involves binding at the:
    Antwoord
    (B)
    Allosteric site
  • 24
    How does an irreversible inhibitor typically bind to an enzyme?
    Antwoord
    (B)
    Irreversibly
  • 25
    Penicillin's inhibition mechanism can be described as:
    Antwoord
    (B)
    Suicide inhibition.
  • 26
    LDH1 is composed of what combination of subunits?
    Antwoord
    (A)
    M and H
  • 27
    A characteristic of irreversible inhibitors is that they:
    Antwoord
    (B)
    Often form covalent bonds with the enzyme.
  • 28
    What is the general function of oxidoreductase enzymes?
    Antwoord
    (B)
    Catalyzing oxidation-reduction reactions.
  • 29
    The Michaelis constant (Km) is:
    Antwoord
    (C)
    The substrate concentration at 1/2 Vmax
  • 30
    Which of the following is NOT a characteristic of noncompetitive inhibitors?
    Antwoord
    (C)
    They affect the Km.
  • 31
    Which enzyme is used to treat leukemia?
    Antwoord
    (A)
    Asparaginase
  • 32
    Irreversible inhibitors bind to the enzyme with:
    Antwoord
    (B)
    Strong affinity
  • 33
    Enzymes increase reaction rate by:
    Antwoord
    (D)
    Decreasing the rate of activation
  • 34
    Penicillin is best described as which type of inhibitor?
    Antwoord
    (B)
    Suicide
  • 35
    Which of the following is a key factor influencing enzyme activity?
    Antwoord
    (D)
    All of the above
  • 36
    LDH1 is primarily found in:
    Antwoord
    (A)
    Heart
  • 37
    Which of the following enzyme levels increases in obstructive jaundice?
    Antwoord
    B
    C
  • 38
    The alkaline phosphatases belong to:
    Antwoord
    A
    C
  • 39
    The optimum temperature for most enzymes is:
    Antwoord
    (B)
    37°C
  • 40
    Which model is more accurate to describe the specific interactions between the enzyme and the substrate?
    Antwoord
    (B)
    Induced Fit Model
  • 41
    Allosteric enzymes are regulated by binding at the:
    Antwoord
    (B)
    Regulatory site
  • 42
    Aspirin inhibits the enzyme:
    Antwoord
    (B)
    Cyclooxygenase
  • 43
    Isozymes are different forms of an enzyme that:
    Antwoord
    (B)
    Catalyze the same reaction
  • 44
    DDT can inhibit which enzyme?
    Antwoord
    (A)
    Acetylcholine esterase
  • 45
    Which of the following is the function of an inhibitor?
    Antwoord
    (B)
    Decreases enzyme activity
  • 46
    Irreversible inhibitors generally interact with enzymes through what type of bonds?
    Antwoord
    (B)
    Covalent bonds
  • 47
    The enzyme acetylcholine esterase is inhibited by:
    Antwoord
    (A)
    DDT (DFP)
  • 48
    Isozymes can be characterized as:
    Antwoord
    (D)
    Multiple forms of given enzyme that catalyze same type of reactions
  • 49
    The mechanism of action for Penicillin involves:
    Antwoord
    (B)
    Suicide Inhibition
  • 50
    Which factors are involved in the activation of the enzyme's activity?
    Antwoord
    A
    B