Essential Biochemistry - Acid Base Balance (Section 1)

  • 1
    At blood pH 7.4, the ratio of HPO4/H2PO4 will be
    Antwoord
    (A)
    4:1
  • 2
    Which buffer system is the most important in the renal tubules?
    Antwoord
    (D)
    Ammonia buffer system
  • 3
    Which of the following is/are key element(s) of the phosphate buffer system?
    Antwoord
    A
    B
  • 4
    What does the anion gap measure?
    Antwoord
    (B)
    The difference between the measured cations and anions in the plasma.
  • 5
    Which of the following conditions can lead to respiratory alkalosis?
    Antwoord
    A
    C
  • 6
    The most important extracellular buffer system is
    Antwoord
    (C)
    Bicarbonate buffer
  • 7
    What is the role of the kidney in acid-base balance?
    Antwoord
    A
    B
    D
  • 8
    What is the normal ratio of bicarbonate to carbonic acid in the blood?
    Antwoord
    (C)
    20:1
  • 9
    What is the main stimulus for the respiratory center to increase ventilation?
    Antwoord
    (C)
    High levels of CO2 in the blood.
  • 10
    Which of the following is volatile acid?
    Antwoord
    (C)
    Carbonic acid
  • 11
    Which of the following are causes of metabolic acidosis?
    Antwoord
    A
    B
    D
  • 12
    Normal range of arterial blood pH is
    Antwoord
    (A)
    7.35-7.45
  • 13
    Physiologically important carbonic acid (H2CO3) present in the body is equivalent in:
    Antwoord
    (B)
    in terms of 0.1 N acid
  • 14
    Which of the following conditions is associated with a decreased anion gap?
    Antwoord
    (C)
    Hypoalbuminemia
  • 15
    Respiratory acidosis results from
    Antwoord
    (A)
    Obstruction to respiration
  • 16
    Important buffer in the intracellular fluid is
    Antwoord
    (A)
    Protein
  • 17
    All of the following are associated with metabolic alkalosis, except
    Antwoord
    (D)
    Decrease in bicarbonate plasma levels
  • 18
    The ionized plasma is maintained by all of the following, except
    Antwoord
    (D)
    None of the above
  • 19
    Which of the following is NOT a buffer in the blood?
    Antwoord
    (D)
    Sodium chloride
  • 20
    Which of the following are the physiological buffer systems?
    Antwoord
    A
    B
    C
  • 21
    At blood pH 7.4 the ratio of NaHCO3/H2CO3 will be
    Antwoord
    (B)
    10:1
  • 22
    What are the key functions of buffer systems in the body?
    Antwoord
    A
    B
  • 23
    What is the effect of increased hydrogen ion concentration (H+) on pH?
    Antwoord
    (B)
    Decreases pH.
  • 24
    Normal pH of blood in
    Antwoord
    (B)
    7.4
  • 25
    Which of the following is NOT a cause of metabolic alkalosis?
    Antwoord
    (D)
    Diabetic ketoacidosis
  • 26
    What is the primary function of the renal mechanism in acid-base balance?
    Antwoord
    (B)
    To excrete or reabsorb bicarbonate and hydrogen ions.
  • 27
    What is the Henderson-Hasselbalch equation?
    Antwoord
    (A)
    pH = pKa + log ([A-]/[HA])
  • 28
    What is the main function of buffers?
    Antwoord
    (B)
    To maintain a constant pH.
  • 29
    In compensated metabolic acidosis, plasma
    Antwoord
    (D)
    Some of the above
  • 30
    Carbonic acid (H2CO3) is buffered by:
    Antwoord
    (A)
    Bicarbonate buffer
  • 31
    Which of the following is the cause of respiratory acidosis?
    Antwoord
    (B)
    Hypoventilation
  • 32
    The first line of defense against acid-base disturbances is
    Antwoord
    (A)
    Buffer mechanism
  • 33
    What are the compensatory mechanisms for metabolic acidosis?
    Antwoord
    A
    B
    D
  • 34
    Metabolic acidosis is associated with all of the following, except
    Antwoord
    (C)
    Decreased formation of ammonia
  • 35
    The respiratory mechanism regulates the concentration of
    Antwoord
    (D)
    All of the above
  • 36
    In the lungs, what is the function of carbonic anhydrase (CA)?
    Antwoord
    (B)
    To convert H2CO3 to CO2 and H2O.
  • 37
    Which of the following is a characteristic of metabolic alkalosis?
    Antwoord
    (C)
    Elevated blood pH and increased HCO3-
  • 38
    What is the primary buffer in the erythrocytes?
    Antwoord
    (D)
    Hemoglobin
  • 39
    The main intracellular buffer system is
    Antwoord
    (C)
    Protein buffer
  • 40
    Metabolic acidosis is primarily due to
    Antwoord
    (D)
    Decrease in bicarbonate
  • 41
    How does the respiratory system compensate for metabolic acidosis?
    Antwoord
    (B)
    Increased ventilation
  • 42
    Which mechanism is primarily involved in the third line of defense in maintaining the blood pH?
    Antwoord
    (C)
    Renal mechanism
  • 43
    In metabolic acidosis, which compensatory mechanism is used?
    Antwoord
    (A)
    Increased respiratory rate
  • 44
    What is the role of the respiratory system in maintaining pH balance?
    Antwoord
    (B)
    Excreting CO2
  • 45
    Which condition is characterized by a decrease in bicarbonate and a decrease in blood pH?
    Antwoord
    (B)
    Metabolic acidosis
  • 46
    Which of the following are the main components of the phosphate buffer system?
    Antwoord
    A
    B
  • 47
    In compensated metabolic acidosis, plasma:
    Antwoord
    (B)
    Total CO₂ content is increased
  • 48
    Respiratory acidosis results from:
    Antwoord
    (A)
    Obstruction to respiration
  • 49
    The respiratory system compensates for metabolic acidosis by:
    Antwoord
    (A)
    Increasing ventilation
  • 50
    In respiratory acidosis, the primary abnormality is:
    Antwoord
    (C)
    Increased PCO2