Essential Biochemistry - Enzymes (Section 6)
1
In allosteric enzyme regulation, an enzyme is specifically for:
2
Which enzyme is directly inhibited by DFP?
3
Which type of inhibitor binds only to the enzyme-substrate complex?
4
What is the effect of a noncompetitive inhibitor on Vmax?
5
Noncompetitive inhibitors bind to the:
6
The elevation of which enzyme is strongly associated with myocardial infarction?
7
In allosteric regulation, the modulator binds to:
8
Dilsulfiram's mechanism of action involves inhibition of:
9
Transaminase enzymes belong to the class:
10
Competitive inhibitors bind to the:
11
Which of the following describes the lock-and-key model of enzyme-substrate interaction?
Odpověď(C)
The substrate fits perfectly into the active site.
12
What type of inhibitor binds to a site other than the active site, altering the enzyme's shape?
13
DDT's mode of action, classifying it as an inhibitor, is:
Odpověď(C)
Group-specific irreversible
14
In obstructive jaundice, which enzymes increase?
15
In a Lineweaver-Burk plot, the x-intercept represents:
16
The Michaelis constant (Km) is a measure of:
Odpověď(B)
The substrate concentration at half Vmax
18
What is the effect of a competitive inhibitor on Vmax?
19
Dilsulfiram's effect results in what physiological consequence?
Odpověď(B)
Build-up of acetaldehyde.
20
LDH1 is a tetramer, made up of two types of polypeptide:
Odpověď(A)
M (muscle) type and H(heart) type
21
Which of the following is an example of an isomerase?
22
Examples of noncompetitive inhibitors are:
23
Which of the following enzyme classes is involved in joining two molecules together with the hydrolysis of ATP?
24
The LDH1 isozyme is composed of:
25
Which is an example of a group-specific irreversible inhibitor?
26
Which of the following affects the velocity of an enzyme-catalyzed reaction?
27
In feedback inhibition, the enzyme inhibited is typically:
Odpověď(B)
The first enzyme in the pathway.
28
Which enzyme does DFP primarily target?
29
The digestive enzymes belong to:
30
The isozymes are classified according to:
31
In feedback inhibition, the product of the pathway acts as an inhibitor. Which enzyme does this product inhibit?
Odpověď(B)
The first enzyme in the pathway
32
What is the principal use of Asparaginase?
33
The substrate concentration at which an enzyme inhibitor has half the maximum velocity is known as:
34
Penicillin functions as what type of inhibitor?
Odpověď(C)
Mechanism-based (suicide)
35
Which of these enzymes is elevated in acute pancreatitis?
36
Which applications utilize enzymes?
37
Elevation of CK-MB is indicative of:
38
Which of the following is true regarding the Lineweaver-Burk plot?
Odpověď(B)
It is a double-reciprocal plot.
39
What happens to the free energy of activation in the presence of an enzyme?
40
Which of the following drugs are noncompetitive inhibitors?
41
Which of the following non-proteins can act as an enzyme?
42
Where is CK-MB primarily found?
43
Aspirin is primarily used to inhibit:
44
What happens to enzyme activity at high temperatures?
45
Which of the following is an example of group specific irreversible inhibitor?
46
Irreversible inhibitors form:
Odpověď(A)
A stable complex with the enzyme
47
Which is an example of a suicide inhibitor?
48
Which is an example of an enzyme that can be used for diagnostic purposes?
49
Which of the following is an example of suicide inhibitor or mechanism based inactivation?
50
LDH1 is composed of which subunit types?
