Quick Biochemistry - Nucleic Acids (Section 1)

  • 1
    What components combine to form a nucleoside?
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    (B)
    A purine or pyrimidine base and a sugar
  • 2
    Which of the following best describes the composition of a nucleotide?
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    (B)
    A purine and pyrimidine base, a sugar, and phosphorous
  • 3
    Which of the following is classified as a purine nucleotide?
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    (A)
    AMP
  • 4
    Which option represents a pyrimidine nucleotide?
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    (C)
    CMP
  • 5
    Adenine is also known as:
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    (A)
    6-Amino purine
  • 6
    What is the other name for 2, 4-Dioxypyrimidine?
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    (C)
    Uracil
  • 7
    What is the chemical designation for guanine?
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    (B)
    2-Amino-6-oxypurine
  • 8
    In what units are the concentrations of nucleotides and nucleic acids frequently expressed?
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    (D)
    OD at 260 nm
  • 9
    Which pyrimidine nucleotide is involved in high-energy intermediate reactions?
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    (C)
    UDPG
  • 10
    In a nucleotide, what carbon position on the pentose molecule is involved in an ester bond with phosphate?
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    (D)
    C₅
  • 11
    What molecule results from the combination of uracil and ribose?
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    (A)
    Uridine
  • 12
    Which nucleotide is most prevalent in a free state within animal cells?
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    (A)
    ATP
  • 13
    Approximately what is the average intracellular concentration of ATP in a mammalian cell?
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    (A)
    1 mM
  • 14
    Which base is present in messenger RNA but absent in deoxyribonucleic acid?
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    (D)
    Uracil
  • 15
    What is the function of 'Caps' in an RNA molecule?
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    (B)
    Are unique to eukaryotic mRNA
  • 16
    How does prokaryotic mRNA differ from eukaryotic mRNA?
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    (A)
    Can be polycistronic
  • 17
    What is the approximate size range of small stable RNA molecules?
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    (C)
    90-300 nucleotides
  • 18
    What is the approximate range of small stable RNAs found within a single cell?
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    (C)
    1,00,000-10,00,000
  • 19
    What is the approximate molecular weight of heterogenous nuclear RNA (hnRNA)?
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    (A)
    More than 107
  • 20
    In RNA, why isn't the guanine content always equal to cytosine, and adenine always equal to uracil?
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    (A)
    Single strand molecule
  • 21
    Which nitrogenous base is found in RNA?
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    (B)
    Uracil
  • 22
    Which of the following is NOT a component of RNA?
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    (C)
    Thymine
  • 23
    What type of sugar is found in RNA?
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    (C)
    Ribose
  • 24
    Which statement accurately describes base pairing in an RNA molecule?
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    (D)
    Guanine content does not necessarily equal its cytosine content.
  • 25
    In which type of RNA are methylated purines and pyrimidines typically found?
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    (C)
    tRNA
  • 26
    Where is Thymine typically found?
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    (A)
    tRNA
  • 27
    What is the approximate number of nucleotides in a tRNA molecule?
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    (C)
    75
  • 28
    In a typical cell, what is the minimum number of different tRNA molecules present?
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    (B)
    20
  • 29
    What shape does a tRNA molecule resemble?
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    (C)
    Clover leaf
  • 30
    In tRNA molecules, the CCA sequence is always located at the:
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    (A)
    3' Termini
  • 31
    What is the basis for classifying Transfer RNAs?
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    (D)
    Extra arm
  • 32
    Which modified base is found in the D arm of a tRNA molecule, giving it its name?
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    (A)
    Uridine
  • 33
    How many base pairs are typically found in the acceptor arm of a tRNA molecule?
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    (B)
    7 Base pairs
  • 34
    How many base pairs does the anticodon arm of a tRNA molecule typically possess?
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    (A)
    5 Base pairs
  • 35
    What sequence is typically found in the TΨC arm of a tRNA molecule?
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    (A)
    T, pseudouridine and C
  • 36
    Who put forth the double helical structure model of DNA?
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    (C)
    Watson and Crick
  • 37
    Which of the following is NOT found in DNA?
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    (C)
    Uracil
  • 38
    What is the type of sugar molecule found in DNA?
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    (A)
    Deoxyribose
  • 39
    DNA segments with a high concentration of A-T pairs are stabilized by how many hydrogen bonds?
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    (B)
    2 Hydrogen bonds
  • 40
    Which statement accurately describes the base composition in a DNA molecule?
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    (D)
    Guanine content equals cytosine content
  • 41
    DNA with a high proportion of G-C pairs tend to have what characteristic regarding hydrogen bonds?
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    (C)
    3 Hydrogen bonds
  • 42
    Given that DNA carries an organism's genetic code, what can be logically inferred about its base composition across different tissues?
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    (C)
    DNA from different tissues in the same organism should usually have the same base composition
  • 43
    What is the approximate width of the B-form DNA double helix in nanometers?
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    (B)
    2
  • 44
    How many base pairs are typically found in a single complete turn of the B-form DNA molecule?
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    (C)
    10
  • 45
    What is the distance, in nanometers, covered by one full turn of B-form DNA?
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    (D)
    3.4 nm
  • 46
    If the thymine concentration in a DNA molecule is 30%, what is the predicted concentration of guanosine?
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    (B)
    20%
  • 47
    If the guanosine content in a DNA molecule is 40%, what would be the percentage of adenine?
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    (A)
    10%
  • 48
    What factor leads to a higher melting temperature in duplex DNA?
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    (C)
    Cytosine + Guanine
  • 49
    What condition is often treated with the synthetic nucleotide analogue, 4-hydroxypyrazolopyrimidine?
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    (B)
    Gout
  • 50
    Which synthetic nucleotide analogue is frequently used in cancer and viral infection treatment?
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    (A)
    Arabinosyl cytosine