Which of the following is an example of feedback allosteric inhibition?
отговор
(A)
Inhibition of the first enzyme in a pathway by the end product.
2
Reliable marker of myocardial infarction is:
отговор
(C)
CK-2
3
What is the role of the enzyme, Trypsin?
отговор
(C)
Digestion of proteins and polypeptides in the small intestine
4
In feedback inhibition, the end product of a metabolic pathway typically acts as a(n):
отговор
(B)
Inhibitor of the first enzyme.
5
What is the role of ATP in some enzyme reactions?
отговор
(B)
It provides energy.
6
What is the major clinical application of the enzyme Collagenase?
отговор
(B)
Removing dead tissue from wounds
7
Which of the following is NOT a characteristic of enzymes?
отговор
(B)
They are consumed in the reaction.
8
What is the name of the model that explains that an enzyme has a rigid shape, like a lock?
отговор
(B)
Lock and key model
9
The enzyme useful in the treatment of leukemia is:
отговор
(B)
Asparaginase
10
What are the main features of competitive inhibitors?
отговор
A
B
C
11
A competitive inhibitor:
отговор
(A)
Binds to the active site.
12
Which of the following is NOT an example of an enzyme used in clinical diagnostics?
отговор
(D)
Trypsin
13
Which type of enzyme inhibitor binds to a site distinct from the active site and, upon binding, alters the enzyme's conformation and catalytic activity?
отговор
(B)
Noncompetitive
14
Which of the following is an example of a mechanism-based inhibitor?
отговор
(B)
Penicillin
15
Transaminases enzyme belong to the class:
отговор
(B)
Transferases
16
What is the primary function of the enzyme, Amylase?
отговор
(C)
Digestion of carbohydrates (starch).
17
What is the role of a catalyst?
отговор
(C)
To speed up a reaction without being consumed.
18
Which type of inhibition does not alter the Km value?
отговор
(B)
Noncompetitive inhibition
19
Which of the following enzyme levels increases in obstructive jaundice?
отговор
C
D
20
Which of the following statements is correct regarding enzyme inhibitors?
отговор
A
C
D
21
How does a competitive inhibitor affect the reaction rate?
отговор
(D)
It can increase or decrease the rate, depending on the substrate concentration.
22
What does the Lineweaver-Burk plot is used for?
отговор
(C)
To determine Vmax and Km values.
23
What is the general role of an isomerase?
отговор
(C)
To catalyze the rearrangement of atoms within a molecule.
24
Enzymes may be used as the following, except:
отговор
(D)
Nutrients
25
What are the common clinical applications of measuring LDH isoenzymes?
отговор
(D)
All of the above
26
How do allosteric enzymes regulate biochemical pathways?
отговор
(C)
By being regulated by modulators
27
Which type of inhibitor affects both the Km and Vmax of an enzyme?
отговор
(C)
Uncompetitive
28
Which inhibitor type results in a decrease in both the Km and Vmax?
отговор
(C)
Uncompetitive inhibitor
29
Which of the following is used in the treatment of some types of leukemia?
отговор
(B)
Asparaginase
30
Which enzyme is useful for dissolving fibrin clots?
отговор
(C)
Streptokinase
31
Which type of enzyme is involved in the transfer of phosphate groups?
отговор
(B)
Transferase
32
The 'lock and key' model explains that the enzyme and substrate:
отговор
(A)
Fit perfectly together.
33
What would be the effect of a non-competitive inhibitor on a Lineweaver-Burk plot?
отговор
(A)
The y-intercept changes and the x-intercept remains the same.
34
Which of the following enzyme classifications catalyze the formation of bonds with the input of ATP?
отговор
(B)
Ligases
35
The Michaelis constant (Km) is:
отговор
(C)
The substrate concentration at 1/2 Vmax
36
What is a common clinical application of measuring lipase?
отговор
(C)
Diagnosis of pancreatitis
37
What is the role of alkaline phosphatase in clinical diagnosis?
отговор
(A)
Diagnosis of liver disease and bone disorders
38
What is the effect of an irreversible inhibitor on an enzyme?
отговор
(B)
It permanently inactivates the enzyme.
39
In which type of enzyme inhibition does the inhibitor bind to a site distinct from the active site, but changes the shape of the active site?
отговор
(B)
Non-competitive inhibition
40
Enzyme activity in biological systems may be affected by the following:
отговор
A
B
C
D
41
Which of the following enzymes is classified as a hydrolase?
отговор
(C)
Amylase
42
Liver diagnostic enzyme is:
отговор
(C)
Alanine transaminase
43
What does Vmax represent?
отговор
(B)
The maximum reaction rate.
44
Which enzyme is elevated in urine in the patient of acute pancreatitis?
отговор
(A)
Amylase
45
What is the normal serum value for adult of Alkaline phosphatase (ALP)?
отговор
(C)
13 to 100 U/L
46
Which of the following can affect enzyme activity?
отговор
A
B
C
D
47
Which enzyme, elevated in serum, is used for diagnosis of acute myocardial infarction?
отговор
(B)
Creatine Kinase (CK-MB)
48
Which of the following is a characteristic of uncompetitive inhibitors?
отговор
(B)
They bind only to the enzyme-substrate complex.
49
What is the primary function of the enzyme amylase?
